International Journal of Infection

Published by: Kowsar

An Overview of Complications and Mortality of Crimean-Congo Hemorrhagic Fever

Hamidreza Kouhpayeh 1 , *
Author Information
1 Tropical and Infectious Diseases Department, Zahedan University of Medical Sciences, Zahedan, Iran
Article information
  • International Journal of Infection: April 30, 2019, 6 (2); e91707
  • Published Online: June 17, 2019
  • Article Type: Review Article
  • Received: March 18, 2019
  • Revised: May 19, 2019
  • Accepted: June 10, 2019
  • DOI: 10.5812/iji.91707

To Cite: Kouhpayeh H. An Overview of Complications and Mortality of Crimean-Congo Hemorrhagic Fever, Int J Infect. 2019 ; 6(2):e91707. doi: 10.5812/iji.91707.

Copyright © 2019, International Journal of Infection. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Conclusions
  • 1. Bente DA. Bunyavirus hemorrhagic fevers, mandell, douglas and bennett᾽s, principles and practice of infectious diseases. 2015.
  • 2. Saebi E. Crimean hemorrhagic fever, text book of infectious diseases in Iran, viral diseases. 1993. p. 607-16.
  • 3. Rodriguez LL, Maupin GO, Ksiazek TG, Rollin PE, Khan AS, Schwarz TF, et al. Molecular investigation of a multisource outbreak of Crimean-Congo hemorrhagic fever in the United Arab Emirates. Am J Trop Med Hyg. 1997;57(5):512-8. doi: 10.4269/ajtmh.1997.57.512. [PubMed: 9392588].
  • 4. Kouhpayeh HR, Naderi M. Epidemiologic and clinical and laboratory evaluation of 18 hospitalized cases of Crimean-Congo hemorrhagic fever in Bu-Ali hospital of Zahedan. Iran J Infect Dis Infect Med. 2002;7:19-22.
  • 5. Alavi-Naini R, Moghtaderi A, Koohpayeh HR, Sharifi-Mood B, Naderi M, Metanat M, et al. Crimean-Congo hemorrhagic fever in Southeast of Iran. J Infect. 2006;52(5):378-82. doi: 10.1016/j.jinf.2005.07.015. [PubMed: 16182370].
  • 6. Ayatollahi J, Shahcheraghi SH, Mirjalili M. Report of nine cases of Crimean-Congo haemorrhagic fever from Iran. Niger Med J. 2015;56(2):156-9. doi: 10.4103/0300-1652.153409. [PubMed: 25838635]. [PubMed Central: PMC4382609].
  • 7. Sharifi-Mood B, Mardani M, Kouhpayeh HR. Compartment syndrome: A very rare complication of Crimean-Congo hemorrhagic fever. Iran J Clin Infect Dis. 2006;1(4):205-8.
  • 8. Agravat V, Agarwal S, Piparva K. Crimean-Congo haemorrhagic fever: An overview. Int J Res Med Sci. 2014;2(2):392-7. doi: 10.5455/2320-6012.ijrms20140504.
  • 9. Kara SS, Kara D, Fettah A. Various clinical conditions can mimic Crimean-Congo hemorrhagic fever in pediatric patients in endemic regions. J Infect Public Health. 2016;9(5):626-32. doi: 10.1016/j.jiph.2016.01.007. [PubMed: 26868277].
  • 10. Kazancioglu S, Akinci E, Bastug A, Kayaaslan B, But A, Aslaner H, et al. Does the course of laboratory parameters help us to predict the outcome of CCHF? Turk J Med Sci. 2016;46(2):328-34. doi: 10.3906/sag-1408-89. [PubMed: 27511493].
  • 11. Ahmeti S, Raka L. Crimean-Congo haemorrhagic fever in Kosova : A fatal case report. Virol J. 2006;3:85. doi: 10.1186/1743-422X-3-85. [PubMed: 17034648]. [PubMed Central: PMC1624825].
  • 12. Onguru P, Dagdas S, Bodur H, Yilmaz M, Akinci E, Eren S, et al. Coagulopathy parameters in patients with Crimean-Congo hemorrhagic fever and its relation with mortality. J Clin Lab Anal. 2010;24(3):163-6. doi: 10.1002/jcla.20383. [PubMed: 20486197].
  • 13. Pshenichnaya NY, Leblebicioglu H, Bozkurt I, Sannikova IV, Abuova GN, Zhuravlev AS, et al. Crimean-Congo hemorrhagic fever in pregnancy: A systematic review and case series from Russia, Kazakhstan and Turkey. Int J Infect Dis. 2017;58:58-64. doi: 10.1016/j.ijid.2017.02.019. [PubMed: 28249811]. [PubMed Central: PMC5421160].
  • 14. Metanat M, Sharifi-Mood B, Alavi-Naini R, Amjadi A. Hepatitis in patients with Crimean–Congo Hemorrhagic fever. Zahedan J Res Med Sci. 2014;16(4):32-4.
  • 15. Sari T, Temocin F, Demirelli M, Oral B, Tulek N. A case of Crimean Congo hemorrhagic fever complicated with pararenal abscess. Arch Clin Infect Dis. 2015;10(4). e28484. doi: 10.5812/archcid.28484.
  • 16. Appannanavar SB, Mishra B. An update on crimean congo hemorrhagic fever. J Glob Infect Dis. 2011;3(3):285-92. doi: 10.4103/0974-777X.83537. [PubMed: 21887063]. [PubMed Central: PMC3162818].
  • 17. Alavi-Naini R, Moghtaderi A, Metanat M. An unusual intracerebral hemorrhage. Can J Infect Dis Med Microbiol. 2004;15(3):175-7. doi: 10.1155/2004/769260. [PubMed: 18159490]. [PubMed Central: PMC2094967].
  • 18. Gulhan B, Kanik-Yuksek S, Cetin ,I, Ozkaya-Parlakay A, Tezer H. Myocarditis in a child with Crimean-Congo hemorrhagic fever. Vector Borne Zoonotic Dis. 2015;15(9):565-7. doi: 10.1089/vbz.2015.1769. [PubMed: 26347941].
  • 19. Gul I, Kaya A, Guven AS, Karapinar H, Kucukdurmaz Z, Yilmaz A, et al. Cardiac findings in children with Crimean-Congo hemorrhagic fever. Med Sci Monit. 2011;17(8):CR457-60. doi: 10.12659/MSM.881907. [PubMed: 21804465].
  • 20. Bastug A, Kayaaslan B, But A, Aslaner H, Sertcelik A, Akinci E, et al. A case of Crimean-Congo hemorrhagic fever complicated with acute pancreatitis. Vector Borne Zoonotic Dis. 2014;14(11):827-9. doi: 10.1089/vbz.2014.1623. [PubMed: 25409276].
  • 21. World Health Organization. Crimean-Congo hemorrhagic fever, key facts. 31 Jan 2013.
  • 22. Oztoprak B, Oztoprak I, Engin A. Is the brain spared in Crimean-Congo haemorrhagic fever? An MR-SWI study to reveal CNS involvement. Eur Radiol. 2018;28(9):3893-901. doi: 10.1007/s00330-018-5310-9. [PubMed: 29532238].
  • 23. Tarvenir C, Ozkurt Z. . Turkish German Gynecology Congress at April 30th -May 4th,. Antalya, Turkey. 2014.
  • 24. Yılmaz R, Karaaslan E, Gül A, Albayrak SE, Kasap T. The analysis of pediatric intensive care unit admissions of crimean congo hemorrhagic fever patients in the most endemic region in Turkey. Erciyes Med J. 2018;40(1). S16.
  • 25. Iranian Health Ministry. Iranian Health Ministry, Health Deputy, Zoonosis Department. April 2019. Available from:

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .
Readers' Comments