International Journal of Infection

Published by: Kowsar

Seroprevalence and Molecular Detection of Hepatitis Delta Virus (HDV) Among Hemodialysis Patients and Blood Donors in a Cross-Sectional Study in Khartoum State, Sudan

Osama Mohamed Mohmed Khair 1 , * , Khalid Abd Allah Enan 2 , Mohammed Osman Hussien 1 , Abdalhafeez Abd Alazeem Mohammed 1 , Mithat A. Bozdayi 3 , Ersin Karatayli 3 , Abd Alrheem Mohamed Elhussein 4 , Isam Mohammed Elkhider 5 and Cihan Yurdaydin 3
Authors Information
1 Department of Virology, Central Laboratory, Ministry of Higher Education, Khartoum, Sudan
2 Department of Immunology, Central Laboratory, Ministry of Higher Education, Khartoum, Sudan
3 Hepatology Institute University of Ankara, Ankara, Turkey
4 Institute of veterinary research (IVR) animal resource research corporation (ARRC), Khartoum, Sudan
5 Department of Microbiology and Parasitology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan
Article information
  • International Journal of Infection: July 01, 2016, 3 (3); e35391
  • Published Online: April 9, 2016
  • Article Type: Research Article
  • Received: December 9, 2015
  • Revised: January 7, 2016
  • Accepted: January 7, 2016
  • DOI: 10.17795/iji-35391

To Cite: Mohmed Khair O M, Enan K A A, Hussien M O, Mohammed A A A, Bozdayi M A, et al. Seroprevalence and Molecular Detection of Hepatitis Delta Virus (HDV) Among Hemodialysis Patients and Blood Donors in a Cross-Sectional Study in Khartoum State, Sudan, Int J Infect. 2016 ; 3(3):e35391. doi: 10.17795/iji-35391.

Copyright © 2016, Infectious Diseases and Tropical Medicine Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Rizzetto M, Canese MG, Arico S, Crivelli O, Trepo C, Bonino F, et al. Immunofluorescence detection of new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and in serum of HBsAg carriers. Gut. 1977; 18(12): 997-1003[PubMed]
  • 2. Rizzetto M, Canese MG, Gerin JL, London WT, Sly DL, Purcell RH. Transmission of the hepatitis B virus-associated delta antigen to chimpanzees. J Infect Dis. 1980; 141(5): 590-602[PubMed]
  • 3. Makino S, Chang MF, Shieh CK, Kamahora T, Vannier DM, Govindarajan S, et al. Molecular cloning and sequencing of a human hepatitis delta (delta) virus RNA. Nature. 1987; 329(6137): 343-6[DOI][PubMed]
  • 4. Ivaniushina V, Radjef N, Alexeeva M, Gault E, Semenov S, Salhi M, et al. Hepatitis delta virus genotypes I and II cocirculate in an endemic area of Yakutia, Russia. J Gen Virol. 2001; 82: 2709-18[DOI][PubMed]
  • 5. Gomes-Gouvea MS, Pereira Soares Mdo C, Guedes de Carvalho Mello IM, Brito EM, Pereira Moia Lde J, Bensabath G, et al. Hepatitis D and B virus genotypes in chronically infected patients from the Eastern Amazon Basin. Acta Trop. 2008; 106(3): 149-55[DOI][PubMed]
  • 6. Makuwa M, Mintsa-Ndong A, Souquiere S, Nkoghe D, Leroy EM, Kazanji M. Prevalence and molecular diversity of hepatitis B virus and hepatitis delta virus in urban and rural populations in northern Gabon in central Africa. J Clin Microbiol. 2009; 47(7): 2265-8[DOI][PubMed]
  • 7. Fattovich G, Giustina G, Christensen E, Pantalena M, Zagni I, Realdi G, et al. Influence of hepatitis delta virus infection on morbidity and mortality in compensated cirrhosis type B. The European Concerted Action on Viral Hepatitis (Eurohep). Gut. 2000; 46(3): 420-6[PubMed]
  • 8. Taylor JM. Hepatitis delta virus. Virology. 2006; 344(1): 71-6[DOI][PubMed]
  • 9. Mederacke I, Bremer B, Heidrich B, Kirschner J, Deterding K, Bock T, et al. Establishment of a novel quantitative hepatitis D virus (HDV) RNA assay using the Cobas TaqMan platform to study HDV RNA kinetics. J Clin Microbiol. 2010; 48(6): 2022-9[DOI][PubMed]
  • 10. Radjef N, Gordien E, Ivaniushina V, Gault E, Anais P, Drugan T, et al. Molecular phylogenetic analyses indicate a wide and ancient radiation of African hepatitis delta virus, suggesting a deltavirus genus of at least seven major clades. J Virol. 2004; 78(5): 2537-44[PubMed]
  • 11. Le Gal F, Gault E, Ripault MP, Serpaggi J, Trinchet JC, Gordien E, et al. Eighth major clade for hepatitis delta virus. Emerg Infect Dis. 2006; 12(9): 1447-50[DOI][PubMed]
  • 12. Mudawi HM, Yousif BA. Fulminant hepatic failure in an African setting: etiology, clinical course, and predictors of mortality. Dig Dis Sci. 2007; 52(11): 3266-9[DOI][PubMed]
  • 13. Mahgoub S, Candotti D, El Ekiaby M, Allain JP. Hepatitis B virus (HBV) infection and recombination between HBV genotypes D and E in asymptomatic blood donors from Khartoum, Sudan. J Clin Microbiol. 2011; 49(1): 298-306[DOI][PubMed]
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