International Journal of Infection

Published by: Kowsar

Thrombocytopenia as a Clinical Manifestation of Hepatitis C Among Patients With a Positive Anti-HCV Test

Safia Bano 1 , Javeria Qureshi 2 , Afsheen Raza 1 , * and Khalid Zafar Hashmi 2
Authors Information
1 The Indus Hospital, Korangi Crossing, Karachi, Pakistan
2 Sindh Institute of Urology and Transplantation, Civil Hospital Karachi, Karachi, Pakistan
Article information
  • International Journal of Infection: July 01, 2016, 3 (3); e35094
  • Published Online: June 26, 2016
  • Article Type: Research Article
  • Received: November 28, 2015
  • Revised: December 23, 2015
  • Accepted: December 28, 2015
  • DOI: 10.17795/iji-35094

To Cite: Bano S, Qureshi J, Raza A, Zafar Hashmi K. Thrombocytopenia as a Clinical Manifestation of Hepatitis C Among Patients With a Positive Anti-HCV Test, Int J Infect. 2016 ; 3(3):e35094. doi: 10.17795/iji-35094.

Abstract
Copyright © 2016, Infectious Diseases and Tropical Medicine Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
Acknowledgements
Footnote
References
  • 1. Kwon YC, Ray RB, Ray R. Hepatitis C virus infection: establishment of chronicity and liver disease progression. EXCLI J. 2014; 13: 977-96[PubMed]
  • 2. Hepatitis C. 2009;
  • 3. Raja NS, Janjua KA. Epidemiology of hepatitis C virus infection in Pakistan. J Microbiol Immunol Infect. 2008; 41(1): 4-8[PubMed]
  • 4. Sy T, Jamal MM. Epidemiology of hepatitis C virus (HCV) infection. Int J Med Sci. 2006; 3(2): 41-6[PubMed]
  • 5. Afdhal N, McHutchison J, Brown R, Jacobson I, Manns M, Poordad F, et al. Thrombocytopenia associated with chronic liver disease. J Hepatol. 2008; 48(6): 1000-7[DOI][PubMed]
  • 6. Bashour FN, Teran JC, Mullen KD. Prevalence of peripheral blood cytopenias (hypersplenism) in patients with nonalcoholic chronic liver disease. Am J Gastroenterol. 2000; 95(10): 2936-9[DOI][PubMed]
  • 7. Giannini EG. Review article: thrombocytopenia in chronic liver disease and pharmacologic treatment options. Aliment Pharmacol Ther. 2006; 23(8): 1055-65[DOI][PubMed]
  • 8. Liangpunsakul S, Ulmer BJ, Chalasani N. Predictors and implications of severe hypersplenism in patients with cirrhosis. Am J Med Sci. 2003; 326(3): 111-6[PubMed]
  • 9. Wang CS, Yao WJ, Wang ST, Chang TT, Chou P. Strong association of hepatitis C virus (HCV) infection and thrombocytopenia: implications from a survey of a community with hyperendemic HCV infection. Clin Infect Dis. 2004; 39(6): 790-6[DOI][PubMed]
  • 10. Behnava B, Alavian SM, Ahmadzad AM. The prevalence of thrombocytopenia in patients with chronic hepatitis B and C. Hepat Mon. 2006; 6(2): 67-9
  • 11. Aoki Y, Hirai K, Tanikawa K. Mechanism of thrombocytopenia in liver cirrhosis: kinetics of indium-111 tropolone labelled platelets. Eur J Nucl Med. 1993; 20(2): 123-9[PubMed]
  • 12. Doi T, Homma H, Mezawa S, Kato J, Kogawa K, Sakamaki S, et al. Mechanisms for increment of platelet associated IgG and platelet surface IgG and their implications in immune thrombocytopenia associated with chronic viral liver disease. Hepatol Res. 2002; 24(1): 23[PubMed]
  • 13. Pereira J, Accatino L, Alfaro J, Brahm J, Hidalgo P, Mezzano D. Platelet autoantibodies in patients with chronic liver disease. Am J Hematol. 1995; 50(3): 173-8[PubMed]
  • 14. Panzer S, Seel E. Is there an increased frequency of autoimmune thrombocytopenia in hepatitis C infection? A review. Wien Med Wochenschr. 2003; 153(19-20): 417-20[PubMed]
  • 15. Pawlotsky JM, Bouvier M, Fromont P, Deforges L, Duval J, Dhumeaux D, et al. Hepatitis C virus infection and autoimmune thrombocytopenic purpura. J Hepatol. 1995; 23(6): 635-9[PubMed]
  • 16. Pivetti S, Novarino A, Merico F, Bertero MT, Brunetto MR, Bonino F, et al. High prevalence of autoimmune phenomena in hepatitis C virus antibody positive patients with lymphoproliferative and connective tissue disorders. Br J Haematol. 1996; 95(1): 204-11[PubMed]
  • 17. Pockros PJ, Duchini A, McMillan R, Nyberg LM, McHutchison J, Viernes E. Immune thrombocytopenic purpura in patients with chronic hepatitis C virus infection. Am J Gastroenterol. 2002; 97(8): 2040-5[DOI][PubMed]
  • 18. Aster RH. Pooling of platelets in the spleen: role in the pathogenesis of "hypersplenic" thrombocytopenia. J Clin Invest. 1966; 45(5): 645-57[DOI][PubMed]
  • 19. Kaushansky K. Thrombopoietin and the hematopoietic stem cell. Blood. 1998; 92(1): 1-3[PubMed]
  • 20. Sharma P, McDonald GB, Banaji M. The risk of bleeding after percutaneous liver biopsy: relation to platelet count. J Clin Gastroenterol. 1982; 4(5): 451-3[PubMed]
  • 21. Dienstag JL, McHutchison JG. American Gastroenterological Association technical review on the management of hepatitis C. Gastroenterology. 2006; 130(1): 231-64[DOI][PubMed]
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