International Journal of Infection

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Prosthetic Joint Infections Due to Coagulase-Negative Staphylococci

Morad Mohamad 1 , * , Luca Deabate 1 , Wilson Belaieff 1 , Cindy Bouvet 1 , Mathieu Zingg 1 , Paulina Kuczma 1 , Domizio Suva 1 and Ilker Uckay 1 , 2
Authors Information
1 Orthopedic Surgery Service, Faculty of Medicine, University Hospitals of Geneva, University of Geneva, Geneva, Switzerland
2 Faculty of Medicine, Infectious Diseases Service, University Hospitals of Geneva, University of Geneva, Geneva, Switzerland
Article information
  • International Journal of Infection: January 01, 2016, 3 (1); e32883
  • Published Online: December 30, 2015
  • Article Type: Review Article
  • Received: September 13, 2015
  • Revised: October 18, 2015
  • Accepted: October 28, 2015
  • DOI: 10.17795/iji-32883

To Cite: Mohamad M, Deabate L, Belaieff W, Bouvet C, Zingg M, et al. Prosthetic Joint Infections Due to Coagulase-Negative Staphylococci, Int J Infect. 2016 ; 3(1):e32883. doi: 10.17795/iji-32883.

Abstract
Copyright © 2015, Infectious Diseases and Tropical Medicine Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Conclusions
Acknowledgements
Footnote
References
  • 1. Uckay I, Lubbeke A, Harbarth S, Emonet S, Tovmirzaeva L, Agostinho A, et al. Low risk despite high endemicity of methicillin-resistant Staphylococcus aureus infections following elective total joint arthroplasty: a 12-year experience. Ann Med. 2012; 44(4): 360-8[DOI][PubMed]
  • 2. Uckay I, Harbarth S, Ferry T, Lubbeke A, Emonet S, Hoffmeyer P, et al. Meticillin resistance in orthopaedic coagulase-negative staphylococcal infections. J Hosp Infect. 2011; 79(3): 248-53[DOI][PubMed]
  • 3. Kloos WE, Bannerman TL. Update on clinical significance of coagulase-negative staphylococci. Clin Microbiol Rev. 1994; 7(1): 117-40[PubMed]
  • 4. Uckay I, Pittet D, Vaudaux P, Sax H, Lew D, Waldvogel F. Foreign body infections due to Staphylococcus epidermidis. Ann Med. 2009; 41(2): 109-19[DOI][PubMed]
  • 5. Adler H, Widmer A, Frei R. Emergence of a teicoplanin-resistant small colony variant of Staphylococcus epidermidis during vancomycin therapy. Eur J Clin Microbiol Infect Dis. 2003; 22(12): 746-8[DOI][PubMed]
  • 6. Darouiche RO. Treatment of infections associated with surgical implants. N Engl J Med. 2004; 350(14): 1422-9[DOI][PubMed]
  • 7. Zimmerli W, Trampuz A, Ochsner PE. Prosthetic-joint infections. N Engl J Med. 2004; 351(16): 1645-54[DOI][PubMed]
  • 8. Steckelberg JM, Osmon DR. Infections associated with indwelling medical devices. 2000; : 173_209
  • 9. Moran E, Masters S, Berendt AR, McLardy-Smith P, Byren I, Atkins BL. Guiding empirical antibiotic therapy in orthopaedics: The microbiology of prosthetic joint infection managed by debridement, irrigation and prosthesis retention. J Infect. 2007; 55(1): 1-7[DOI][PubMed]
  • 10. Uckay I, Teterycz D, Ferry T, Harbarth S, Lubbeke A, Emonet S, et al. Poor utility of MRSA screening to predict staphylococcal species in orthopaedic implant infections. J Hosp Infect. 2009; 73(1): 89-91[DOI][PubMed]
  • 11. Teterycz D, Ferry T, Lew D, Stern R, Assal M, Hoffmeyer P, et al. Outcome of orthopedic implant infections due to different staphylococci. Int J Infect Dis. 2010; 14(10)-8[DOI][PubMed]
  • 12. Garzoni C, Uckay I, Belaieff W, Breilh D, Suva D, Huggler E, et al. In vivo interactions of continuous flucloxacillin infusion and high-dose oral rifampicin in the serum of 15 patients with bone and soft tissue infections due to Staphylococcus aureus - a methodological and pilot study. Springerplus. 2014; 3: 287[DOI][PubMed]
  • 13. National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control. 2004; 32(8): 470
  • 14. Mohanty SS, Kay PR. Infection in total joint replacements. Why we screen MRSA when MRSE is the problem? J Bone Joint Surg Br. 2004; 86(2): 266-8[PubMed]
  • 15. Thore M, Kuhn I, Lofdahl S, Burman LG. Drug-resistant coagulase-negative skin staphylococci. Evaluation of four marker systems and epidemiology in an orthopaedic ward. Epidemiol Infect. 1990; 105(1): 95-105[PubMed]
  • 16. Widerstrom M, Monsen T, Karlsson C, Wistrom J. Molecular epidemiology of meticillin-resistant coagulase-negative staphylococci in a Swedish county hospital: evidence of intra- and interhospital clonal spread. J Hosp Infect. 2006; 64(2): 177-83[DOI][PubMed]
  • 17. Sanzen L, Walder M. Antibiotic resistance of coagulase-negative staphylococci in an orthopaedic department. J Hosp Infect. 1988; 12(2): 103-8[PubMed]
  • 18. Kitao T. Survey of methicillin-resistant coagulase-negative staphylococci isolated from the fingers of nursing students. J Infect Chemother. 2003; 9(1): 30-4[DOI][PubMed]
  • 19. James PJ, Butcher IA, Gardner ER, Hamblen DL. Methicillin-resistant Staphylococcus epidermidis in infection of hip arthroplasties. J Bone Joint Surg Br. 1994; 76(5): 725-7[PubMed]
  • 20. Uckay I, Hoffmeyer P, Lew D, Pittet D. Prevention of surgical site infections in orthopaedic surgery and bone trauma: state-of-the-art update. J Hosp Infect. 2013; 84(1): 5-12[DOI][PubMed]
  • 21. Uckay I, Lubbeke A, Emonet S, Tovmirzaeva L, Stern R, Ferry T, et al. Low incidence of haematogenous seeding to total hip and knee prostheses in patients with remote infections. J Infect. 2009; 59(5): 337-45[DOI][PubMed]
  • 22. Costerton JW, Lewandowski Z, Caldwell DE, Korber DR, Lappin-Scott HM. Microbial biofilms. Annu Rev Microbiol. 1995; 49: 711-45[DOI][PubMed]
  • 23. von Eiff C, Peters G, Heilmann C. Pathogenesis of infections due to coagulasenegative staphylococci. Lancet Infect Dis. 2002; 2(11): 677-85[DOI]
  • 24. Arciola CR, Baldassarri L, Montanaro L. Presence of icaA and icaD genes and slime production in a collection of staphylococcal strains from catheter-associated infections. J Clin Microbiol. 2001; 39(6): 2151-6[DOI][PubMed]
  • 25. Vadyvaloo V, Otto M. Molecular genetics of Staphylococcus epidermidis biofilms on indwelling medical devices. Int J Artif Organs. 2005; 28(11): 1069-78[PubMed]
  • 26. Mack D, Davies AP, Harris LG, Rohde H, Horstkotte MA, Knobloch JK. Microbial interactions in Staphylococcus epidermidis biofilms. Anal Bioanal Chem. 2007; 387(2): 399-408[DOI][PubMed]
  • 27. Bernard L, Hoffmeyer P, Assal M, Vaudaux P, Schrenzel J, Lew D. Trends in the treatment of orthopaedic prosthetic infections. J Antimicrob Chemother. 2004; 53(2): 127-9[DOI][PubMed]
  • 28. Kaiser AB, Petracek MR, Lea JW, Kernodle DS, Roach AC, Alford WC, et al. Efficacy of cefazolin, cefamandole, and gentamicin as prophylactic agents in cardiac surgery. Results of a prospective, randomized, double-blind trial in 1030 patients. Ann Surg. 1987; 206(6): 791-7[PubMed]
  • 29. Falcone M, Micozzi A, Pompeo ME, Baiocchi P, Fabi F, Penni A, et al. Methicillin-resistant staphylococcal bacteremia in patients with hematologic malignancies: clinical and microbiological retrospective comparative analysis of S. haemolyticus, S. epidermidis and S. aureus. J Chemother. 2004; 16(6): 540-8[DOI][PubMed]
  • 30. Raad I, Alrahwan A, Rolston K. Staphylococcus epidermidis: emerging resistance and need for alternative agents. Clin Infect Dis. 1998; 26(5): 1182-7[PubMed]
  • 31. Trampuz A, Zimmerli W. Antimicrobial agents in orthopaedic surgery: Prophylaxis and treatment. Drugs. 2006; 66(8): 1089-105[PubMed]
  • 32. Classen DC, Evans RS, Pestotnik SL, Horn SD, Menlove RL, Burke JP. The timing of prophylactic administration of antibiotics and the risk of surgical-wound infection. N Engl J Med. 1992; 326(5): 281-6[DOI][PubMed]
  • 33. Cranny G, Elliott R, Weatherly H, Chambers D, Hawkins N, Myers L, et al. A systematic review and economic model of switching from non-glycopeptide to glycopeptide antibiotic prophylaxis for surgery. Health Technol Assess. 2008; 12(1)-1-147[PubMed]
  • 34. Mini E, Nobili S, Periti P. Methicillin-resistant staphylococci in clean surgery. Is there a role for prophylaxis? Drugs. 1997; 54 Suppl 6: 39-52[PubMed]
  • 35. Bolon MK, Morlote M, Weber SG, Koplan B, Carmeli Y, Wright SB. Glycopeptides are no more effective than beta-lactam agents for prevention of surgical site infection after cardiac surgery: a meta-analysis. Clin Infect Dis. 2004; 38(10): 1357-63[DOI][PubMed]
  • 36. Elliott RA, Weatherly HL, Hawkins NS, Cranny G, Chambers D, Myers L, et al. An economic model for the prevention of MRSA infections after surgery: non-glycopeptide or glycopeptide antibiotic prophylaxis? Eur J Health Econ. 2010; 11(1): 57-66[DOI][PubMed]
  • 37. Mandell GL. The antimicrobial activity of rifampin: emphasis on the relation to phagocytes. Rev Infect Dis. 1983; 5 Suppl 3-7[PubMed]
  • 38. Jugun K, Vaudaux P, Garbino J, Pagani L, Hoffmeyer P, Lew D, et al. The safety and efficacy of high-dose daptomycin combined with rifampicin for the treatment of Gram-positive osteoarticular infections. Int Orthop. 2013; 37(7): 1375-80[DOI][PubMed]
  • 39. Widmer AF, Frei R, Rajacic Z, Zimmerli W. Correlation between in vivo and in vitro efficacy of antimicrobial agents against foreign body infections. J Infect Dis. 1990; 162(1): 96-102[PubMed]
  • 40. Monzon M, Oteiza C, Leiva J, Amorena B. Synergy of different antibiotic combinations in biofilms of Staphylococcus epidermidis. J Antimicrob Chemother. 2001; 48(6): 793-801[PubMed]
  • 41. Widmer AF, Gaechter A, Ochsner PE, Zimmerli W. Antimicrobial treatment of orthopedic implant-related infections with rifampin combinations. Clin Infect Dis. 1992; 14(6): 1251-3[PubMed]
  • 42. Archer GL, Johnston JL, Vazquez GJ, Haywood HB. Efficacy of antibiotic combinations including rifampin against methicillin-resistant Staphylococcus epidermidis: in vitro and in vivo studies. Rev Infect Dis. 1983; 5 Suppl 3-42[PubMed]
  • 43. Drancourt M, Stein A, Argenson JN, Roiron R, Groulier P, Raoult D. Oral treatment of Staphylococcus spp. infected orthopaedic implants with fusidic acid or ofloxacin in combination with rifampicin. J Antimicrob Chemother. 1997; 39(2): 235-40[PubMed]
  • 44. Saginur R, Stdenis M, Ferris W, Aaron SD, Chan F, Lee C, et al. Multiple combination bactericidal testing of staphylococcal biofilms from implant-associated infections. Antimicrob Agents Chemother. 2006; 50(1): 55-61[DOI][PubMed]
  • 45. Aslam S, Trautner BW, Ramanathan V, Darouiche RO. Combination of tigecycline and N-acetylcysteine reduces biofilm-embedded bacteria on vascular catheters. Antimicrob Agents Chemother. 2007; 51(4): 1556-8[DOI][PubMed]
  • 46. LaPlante KL, Mermel LA. In vitro activity of daptomycin and vancomycin lock solutions on staphylococcal biofilms in a central venous catheter model. Nephrol Dial Transplant. 2007; 22(8): 2239-46[DOI][PubMed]
  • 47. Mogenet I, Raetz-Dillon S, Canonge JM, Archambaud M, Bonnet E. Successful treatment of Staphylococcus epidermidis hip prosthesis infection with oral linezolid. Ann Pharmacother. 2004; 38(6): 986-8[DOI][PubMed]
  • 48. Isiklar ZU, Darouiche RO, Landon GC, Beck T. Efficacy of antibiotics alone for orthopaedic device related infections. Clin Orthop Relat Res. 1996; (332): 184-9[PubMed]
  • 49. Gagnon RF, Richards GK, Kostiner GB. Time-kill efficacy of antibiotics in combination with rifampin against Staphylococcus epidermidis biofilms. Adv Perit Dial. 1994; 10: 189-92[PubMed]
  • 50. Zimmerli W, Widmer AF, Blatter M, Frei R, Ochsner PE. Role of rifampin for treatment of orthopedic implant-related staphylococcal infections: a randomized controlled trial. Foreign-Body Infection (FBI) Study Group. JAMA. 1998; 279(19): 1537-41[PubMed]
  • 51. Soriano A, Jurado A, Marco F, Almela M, Ortega M, Mensa J. [In vitro activity of linezolid, moxifloxacin, levofloxacin, clindamycin and rifampin, alone and in combination, against Staphylococcus aureus and Staphylococcus epidermidis]. Rev Esp Quimioter. 2005; 18(2): 168-72[PubMed]
  • 52. Lemmen SW, Hafner H, Klik S, Lutticken R, Zolldann D. Comparison of the bactericidal activity of moxifloxacin and levofloxacin against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Klebsiella pneumoniae. Chemotherapy. 2003; 49(1-2): 33-5[DOI][PubMed]
  • 53. Uckay I, Jugun K, Gamulin A, Wagener J, Hoffmeyer P, Lew D. Chronic osteomyelitis. Curr Infect Dis Rep. 2012; 14(5): 566-75[DOI][PubMed]
  • 54. Uckay l, Laurent F, Lustig S, et al. Hospital and community-acquired methicillin-resistant Staphylococcus aureus bone and joint infections. In: Methicillin-resistant Staphylococcus aureus. Chapter 4: 2009 Nova Science Publishers.
  • 55. Armstrong DG, Lanthier J, Lelievre P, Edelson GW. Methicillin-resistant coagulase-negative staphylococcal osteomyelitis and its relationship to broad-spectrum oral antibiosis in a predominantly diabetic population. J Foot Ankle Surg. 1995; 34(6): 563-6[DOI][PubMed]
  • 56. Galdbart JO, Morvan A, Desplaces N, el Solh N. Phenotypic and genomic variation among Staphylococcus epidermidis strains infecting joint prostheses. J Clin Microbiol. 1999; 37(5): 1306-12[PubMed]
  • 57. Nilsdotter-Augustinsson A, Koskela A, Ohman L, Soderquist B. Characterization of coagulase-negative staphylococci isolated from patients with infected hip prostheses: use of phenotypic and genotypic analyses, including tests for the presence of the ica operon. Eur J Clin Microbiol Infect Dis. 2007; 26(4): 255-65[DOI][PubMed]
  • 58. Bernard L, Legout L, Zurcher-Pfund L, Stern R, Rohner P, Peter R, et al. Six weeks of antibiotic treatment is sufficient following surgery for septic arthroplasty. J Infect. 2010; 61(2): 125-32[DOI][PubMed]
  • 59. Piso RJ, Elke R. Antibiotic treatment can be safely stopped in asymptomatic patients with prosthetic joint infections despite persistent elevated C-reactive protein values. Infection. 2010; 38(4): 293-6[DOI][PubMed]
  • 60. Callaghan JJ, Katz RP, Johnston RC. One-stage revision surgery of the infected hip. A minimum 10-year followup study. Clin Orthop Relat Res. 1999; (369): 139-43[PubMed]
  • 61. Anagnostakos K, Kelm J, Regitz T, Schmitt E, Jung W. In vitro evaluation of antibiotic release from and bacteria growth inhibition by antibiotic-loaded acrylic bone cement spacers. J Biomed Mater Res B Appl Biomater. 2005; 72(2): 373-8[DOI][PubMed]
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