International Journal of Infection

Published by: Kowsar

Antifungal Susceptibility of Candida Species Isolated from Cancer Patients with Oral Lesions Undergoing Chemotherapy

Zahra Jabalameli 1 , Ali-Mohammad Sabzghabaee 2 , Mohammad-Ali Mohaghegh 1 , Mehrnoosh Maherolnaghsh 1 , 3 , Hossein Safavizadeh 4 and Parvin Dehghan 1 , *
Authors Information
1 Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Medical Mycoparasitology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4 Rahjuyan Institute of Health, Isfahan, Iran
Article information
  • International Journal of Infection: October 2017, 4 (4); e14178
  • Published Online: June 7, 2017
  • Article Type: Research Article
  • Received: January 7, 2017
  • Accepted: January 14, 2017
  • DOI: 10.5812/iji.14178

To Cite: Jabalameli Z, Sabzghabaee A, Mohaghegh M, Maherolnaghsh M, Safavizadeh H, et al. Antifungal Susceptibility of Candida Species Isolated from Cancer Patients with Oral Lesions Undergoing Chemotherapy, Int J Infect. 2017 ; 4(4):e14178. doi: 10.5812/iji.14178.

Copyright © 2017, International Journal of Infection. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Akpan A, Morgan R. Oral candidiasis. Postgrad Med J. 2002; 78(922): 455-9[PubMed]
  • 2. Fraser VJ, Jones M, Dunkel J, Storfer S, Medoff G, Dunagan WC. Candidemia in a tertiary care hospital: epidemiology, risk factors, and predictors of mortality. Clin Infect Dis. 1992; 15(3): 414-21[PubMed]
  • 3. Jackson BE, Wilhelmus KR, Mitchell BM. Genetically regulated filamentation contributes to Candida albicans virulence during corneal infection. Microb Pathog. 2007; 42(2-3): 88-93[DOI][PubMed]
  • 4. Maheronnaghsh M, Tolouei S, Dehghan P, Chadeganipour M, Yazdi M. Identification of Candida species in patients with oral lesion undergoing chemotherapy along with minimum inhibitory concentration to fluconazole. Adv Biomed Res. 2016; 5: 132[DOI][PubMed]
  • 5. Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer-Jensen M, et al. Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer. 2004; 100(9 Suppl): 1995-2025[DOI][PubMed]
  • 6. Meurman JH, Uittamo J. Oral micro-organisms in the etiology of cancer. Acta Odontol Scand. 2008; 66(6): 321-6[DOI][PubMed]
  • 7. Shokohi T, Bandalizadeh Z, Hedayati M, Mayahi S. In vitro antifungal susceptibility of Candida species isolated from oropharyngeal lesions of patients with cancer to some antifungal agents. Jundishapur J Microbiol. 2011; 4(2): 19-26
  • 8. Badiee P, Alborzi A, Davarpanah MA, Shakiba E. Distributions and antifungal susceptibility of Candida species from mucosal sites in HIV positive patients. Arch Iran Med. 2010; 13(4): 282-7[PubMed]
  • 9. Shokohi T, Hashemi Soteh MB, Saltanat Pouri Z, Hedayati MT, Mayahi S. Identification of Candida species using PCR-RFLP in cancer patients in Iran. Indian J Med Microbiol. 2010; 28(2): 147-51[DOI][PubMed]
  • 10. institute C. Reference method for broth dilution antifungal susceptibility testing of yeasts; approved standard- third edition M27-A3, 2008. 2008;
  • 11. Ma CF, Li FQ, Shi LN, Hu YA, Wang Y, Huang M, et al. Surveillance study of species distribution, antifungal susceptibility and mortality of nosocomial candidemia in a tertiary care hospital in China. BMC Infect Dis. 2013; 13: 337[DOI][PubMed]
  • 12. Rex JH, Rinaldi MG, Pfaller MA. Resistance of Candida species to fluconazole. Antimicrob Agents Chemother. 1995; 39(1): 1-8[PubMed]
  • 13. Mohaghegh M, Ghazvini K, Jafari R, Alikhani M, Safari M, Azari-Garamjan G. Retrospective study on the prevalence and antibiotic resistance pattern of staphylococcus aureus and staphylococcus epidermidis among patients suspicious of bacteremia during 2006-2011. Int J Enteric Pathog. 2015; 3(2)
  • 14. Naglik JR, Challacombe SJ, Hube B. Candida albicans secreted aspartyl proteinases in virulence and pathogenesis. Microbiol Mol Biol Rev. 2003; 67(3): 400-28[PubMed]
  • 15. Davies AN, Brailsford SR, Beighton D. Oral candidosis in patients with advanced cancer. Oral Oncol. 2006; 42(7): 698-702[DOI][PubMed]
  • 16. Davies AN, Brailsford SR, Beighton D, Shorthose K, Stevens VC. Oral candidosis in community-based patients with advanced cancer. J Pain Symptom Manage. 2008; 35(5): 508-14[DOI][PubMed]
  • 17. Bhatt VR, Viola GM, Ferrajoli A. Invasive fungal infections in acute leukemia. Ther Adv Hematol. 2011; 2(4): 231-47[DOI][PubMed]
  • 18. Gotzsche PC, Johansen HK. Nystatin prophylaxis and treatment in severely immunodepressed patients. Cochrane Database Syst Rev. 2002; (4)[DOI][PubMed]
  • 19. Bagg J, Sweeney MP, Lewis MA, Jackson MS, Coleman D, Al MA, et al. High prevalence of non-albicans yeasts and detection of anti-fungal resistance in the oral flora of patients with advanced cancer. Palliat Med. 2003; 17(6): 477-81[DOI][PubMed]
  • 20. Davies A, Brailsford S, Broadley K, Beighton D. Resistance amongst yeasts isolated from the oral cavities of patients with advanced cancer. Palliat Med. 2002; 16(6): 527-31[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments