International Journal of Infection

Published by: Kowsar

Antibacterial and Antibiotic-Potentiation Activities of Levisticum officinale L. Extracts on Pathogenic Bacteria

Azizollah Ebrahimi 1 , * , Atefe Eshraghi 2 , Mohamad Reza Mahzoonieh 1 and Sharareh Lotfalian 1
Authors Information
1 Department of Pathobiology, School of Veterinary Science, Shahrekord University, Shahrekord, IR Iran
2 Department of Pathobiology, Veterinary College, Shahrekord University, Shahrekord, IR Iran
Article information
  • International Journal of Infection: April 2017, 4 (2); e38768
  • Published Online: August 6, 2016
  • Article Type: Research Article
  • Received: April 26, 2016
  • Revised: May 24, 2016
  • Accepted: May 25, 2016
  • DOI: 10.5812/iji.38768

To Cite: Ebrahimi A, Eshraghi A, Mahzoonieh M R, Lotfalian S. Antibacterial and Antibiotic-Potentiation Activities of Levisticum officinale L. Extracts on Pathogenic Bacteria, Int J Infect. 2017 ; 4(2):e38768. doi: 10.5812/iji.38768.

Copyright © 2016, Infectious Diseases and Tropical Medicine Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Piddock LJ. Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. Clin Microbiol Rev. 2006; 19(2): 382-402[DOI][PubMed]
  • 2. Ardebili A, Talebi M, Azimi L, Rastegar Lari A. Effect of Efflux Pump Inhibitor Carbonyl Cyanide 3-Chlorophenylhydrazone on the Minimum Inhibitory Concentration of Ciprofloxacin in Acinetobacter baumannii Clinical Isolates. Jundishapur J Microbiol. 2014; 7(1): 8691[DOI][PubMed]
  • 3. Blot S, Depuydt P, Vandewoude K, De Bacquer D. Measuring the impact of multidrug resistance in nosocomial infection. Curr Opin Infect Dis. 2007; 20(4): 391-6[DOI][PubMed]
  • 4. Lamers RP, Cavallari JF, Burrows LL. The efflux inhibitor phenylalanine-arginine beta-naphthylamide (PAbetaN) permeabilizes the outer membrane of gram-negative bacteria. PLoS One. 2013; 8(3): 60666[DOI][PubMed]
  • 5. Dreier J, Ruggerone P. Interaction of antibacterial compounds with RND e ffl ux pumps in Pseudomonas aeruginosa. Front Microbiol. 2015; 6: 660[DOI][PubMed]
  • 6. Stavri M, Piddock LJ, Gibbons S. Bacterial efflux pump inhibitors from natural sources. J Antimicrob Chemother. 2007; 59(6): 1247-60[DOI][PubMed]
  • 7. Jalali H, Nejad AM, Ebadi AG, Laey G. Ethnobotany and folk pharmaceutical properties of major trees or shrubs in northeast of Iran. Asian J Chem. 2009; 21(7): 5632-8
  • 8. Nejad AS, Kamkar A, Giri A, Pourmahmoudi AA. Ethnobotany and folk medicinal uses of major trees and shrubs in Northern Iran. J Med Plants Res. 2013; 7(7): 284-9
  • 9. Cu J-Q,, Pu F, Shi Y, Perineau F, Delmas M, Gaset A. The chemical composition of lovage headspace and essential oils produced by solvent extraction with various solvents. J Essent Oil Res. 1990; 2(2): 53-9
  • 10. Garvey MI, Rahman MM, Gibbons S, Piddock LJ. Medicinal plant extracts with efflux inhibitory activity against Gram-negative bacteria. Int J Antimicrob Agents. 2011; 37(2): 145-51[DOI][PubMed]
  • 11. Azwanida N. A Review on the extraction methods use in medicinal plants, principle, strength and limitation. J Med Aromat Plants. 2015; 4: 196
  • 12. Wayne P. Clinical and Laboratory Standarts Institute: Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that grow Aerobically 2006;
  • 13. Shahverdi AR, Monsef-Esfahani HR, Tavasoli F, Zaheri A, Mirjani R. Trans-cinnamaldehyde from Cinnamomum zeylanicum bark essential oil reduces the clindamycin resistance of Clostridium difficile in vitro. J Food Sci. 2007; 72(1): 55-8[DOI][PubMed]
  • 14. Braga LC, Leite AA, Xavier KG, Takahashi JA, Bemquerer MP, Chartone-Souza E, et al. Synergic interaction between pomegranate extract and antibiotics against Staphylococcus aureus. Can J Microbiol. 2005; 51(7): 541-7[DOI][PubMed]
  • 15. Martins M, McCusker MP, Viveiros M, Couto I, Fanning S, Pages JM, et al. A Simple Method for Assessment of MDR Bacteria for Over-Expressed Efflux Pumps. Open Microbiol J. 2013; 7: 72-82[DOI][PubMed]
  • 16. Tegos G, Stermitz FR, Lomovskaya O, Lewis K. Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials. Antimicrob Agents Chemother. 2002; 46(10): 3133-41[PubMed]
  • 17. Lorenzi V, Muselli A, Bernardini AF, Berti L, Pages JM, Amaral L, et al. Geraniol restores antibiotic activities against multidrug-resistant isolates from gram-negative species. Antimicrob Agents Chemother. 2009; 53(5): 2209-11[DOI][PubMed]
  • 18. Piddock LJ, Garvey MI, Rahman MM, Gibbons S. Natural and synthetic compounds such as trimethoprim behave as inhibitors of efflux in Gram-negative bacteria. J Antimicrob Chemother. 2010; 65(6): 1215-23[DOI][PubMed]
  • 19. Meot-Duros L, Cerantola S, Talarmin H, Le Meur C, Le Floch G, Magne C. New antibacterial and cytotoxic activities of falcarindiol isolated in Crithmum maritimum L. leaf extract. Food Chem Toxicol. 2010; 48(2): 553-7[DOI][PubMed]
  • 20. Karsha PV, Lakshmi OB. Antibacterial activity of black pepper (Piper nigrum Linn.) with special reference to its mode of action on bacteria. Indian J Nat Prod Resour. 2010; 1(2): 213-5
  • 21. Ono T, Kashimura M, Suzuki K, Oyauchi R, Miyachi J, Ikuta H, et al. In vitro and in vivo antibacterial activities of the tricyclic ketolide TE-802 and its analogs. J Antibiot (Tokyo). 2004; 57(8): 518-27[PubMed]
  • 22. Samiee K, Akhgar MR, Rustaiyan A, Masoudi S. Composition of the volatiles of Ferulago carduchorum Boiss. et Hausskn. and Levisticum officinale Koch. obtained by hydrodistillation and extraction. J Essent Oil Res. 2006; 18(1): 19-22
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments